Electrocardiographic analysis in mice (C57BL/6) inoculated with melanoma (B16F10)

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Abstract

B16F10 cells are a murine melanoma cell line characterized by high metastatic potential and resistance to various treatments. Studies indicate that cancer can cause significant alterations in the heart's electrical conduction system. The aim of this study was to evaluate and compare electrocardiographic tracings in C57BL/6 mice using a non-invasive computerized electrocardiography method, comparing healthy animals and mice inoculated with B16F10 cells. C57BL/6 mice were used and subcutaneously inoculated with B16F10 cells, being divided into a control group and a melanoma group. The animals were monitored over 21 days, with electrocardiographic measurements performed at seven-day intervals. Non-invasive electrodes were used to analyze parameters such as heart rate, amplitude and duration of the P wave, QRS complex, and PR and RR intervals. Changes in heart rate were observed, as well as alterations in PR and RR intervals and in the amplitude and duration of the P and R waves, indicating possible electrical conduction dysfunctions associated with melanoma. These findings suggest that B16F10 inoculation may have a direct impact on the heart’s electrical conduction system, possibly due to the release of inflammatory cytokines or tumor-induced alterations in cardiac metabolism. The presence of electrocardiographic alterations in mice with melanoma reinforces the hypothesis that cancer can affect cardiac function. These results may contribute to a better understanding of the relationship between cancer pathophysiology and cardiovascular diseases and may support the development of new therapeutic strategies aimed at protecting cardiac function during melanoma treatment.
Keywords: Skin cancer; electrocardiogram; Mus musculus; cardiovascular system.

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Published

2026-05-04

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Vol. 27 (2026): Continuous publication

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VETERINARY MEDICINE

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How to Cite

ALMEIDA, P. R. C. DE et al. Electrocardiographic analysis in mice (C57BL/6) inoculated with melanoma (B16F10). Brazilian Animal Science/ Ciência Animal Brasileira, v. 27, 4 May2026.

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