Prognostic markers of multiple organ dysfunction syndrome in critically ill dogs: albumin, creatinine, platelets, RNL, RPL, and shock index

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Abstract

Systemic Inflammatory Response Syndrome (SIRS) is a severe condition in hospitalized dogs, particularly when associated with multiple organ dysfunction syndrome (MODS), which is linked to increased mortality. This study included 39 dogs meeting SIRS criteria, aiming to evaluate clinical and laboratory parameters as prognostic tools at admission. The following variables were analyzed: hematocrit (≤25 %), platelet count (≤200,000/µL), albumin (≤2.5 g/dL), creatinine (≥1.6 mg/dL), serum lactate, shock index (SI), neutrophil-to-lymphocyte ratio (NLR), and platelet-to-lymphocyte ratio (PLR).Dogs were stratified into three groups according to disease severity: Group A (three abnormal laboratory parameters), Group B (two abnormal parameters), and Group C (one abnormal parameter). Mortality was highest in Group A (60 %), followed by Group B (53.8 %) and Group C (36.4 %). Statistically significant differences were observed among groups for hematocrit (p = 0.002), platelet count (p = 0.002), and albumin (p = 0.014).ROC curve analysis demonstrated high sensitivity of the shock index (88.9 %) for predicting mortality. The integrated assessment of simple laboratory parameters and the shock index was useful for risk stratification, whereas the predictive performance of admission lactate and NLR/PLR when evaluated in isolation was limited, possibly influenced by the static nature of measurement and sample size.
Keywords: Prognosis; systemic inflammatory response syndrome; clinical triage.

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Published

2026-05-13

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Vol. 27 (2026): Continuous publication

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VETERINARY MEDICINE

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How to Cite

RUEDA, T.; DITTRICH, R. L. Prognostic markers of multiple organ dysfunction syndrome in critically ill dogs: albumin, creatinine, platelets, RNL, RPL, and shock index. Brazilian Animal Science/ Ciência Animal Brasileira, v. 27, 13 May2026.

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