Efeitos da inflamação induzida por LPS sobre o leucograma e os parâmetros bioquímicos em novilhas de corte confinadas

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Resumo

Bovinos de corte em sistemas de confinamento podem desenvolver doenças associadas à liberação de endotoxinas como, por exemplo, o lipopolissacarídeo (LPS). No entanto, poucos estudos avaliaram a endotoxemia aguda experimental em novilhas de corte. Este estudo teve como objetivo avaliar os efeitos da inflamação induzida por LPS sobre os parâmetros bioquímicos e do leucograma em novilhas de corte confinadas. Dezesseis novilhas de corte foram distribuídas aleatoriamente em dois grupos: o grupo LPS (n = 8), que recebeu duas doses intravenosas de 0,5 μg/kg de peso corporal de LPS de Escherichia coli (O111:B4), administradas com um intervalo de 24 horas entre as injeções, e o grupo controle (CTR, n = 8), que recebeu duas doses intravenosas de solução salina. A temperatura corporal foi medida utilizando termômetros digitais intravaginais por 8 horas após a primeira e 12 horas após a segunda injeção. Amostras de sangue foram coletadas em 0, 4, 8, 24, 28, 32 e 72 horas em relação ao primeiro desafio, para análise hematológica e avaliação do metabolismo energético e lipídico, perfil proteico, enzimas hepáticas, minerais e marcadores inflamatórios. Os dados foram analisados utilizando um modelo de medidas repetidas, incluindo grupo, tempo e a interação grupo x tempo, considerando significância quando P < 0,05. A administração de LPS induziu aumento na temperatura corporal, leucocitose, caracterizada por neutrofilia e monocitose, e redução da paraoxonase-1 (PON1). Esses achados demonstram que a endotoxemia aguda experimental induz alterações predominantemente associadas à resposta inflamatória aguda em novilhas de corte confinadas.
Palavras-chave: fase de resposta aguda; endotoxemia; imunometabolimo; leucocitose; PON1.

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Publicado

2026-07-09

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v. 27 (2026): Publicação contínua

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MEDICINA VETERINÁRIA

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Direitos autorais (c) 2026 Ciência Animal Brasileira / Brazilian Animal Science

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Como Citar

MAFFI, A. S. et al. Efeitos da inflamação induzida por LPS sobre o leucograma e os parâmetros bioquímicos em novilhas de corte confinadas. Ciência Animal Brasileira / Brazilian Animal Science, v. 27, 9 jul.2026.

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