Imunomarcação de tgf-? Em próstatas caninas normais e com lesões proliferativas

Denise Caroline Toledo; Mariana Batista Rodrigues Faleiro; Hugo Henrique Ferreira; Adriana Marques Faria; Moema Pacheco Chediak Matos; Renee Laufer Amorim; Veridiana Maria Brianezi Dignani de Moura

doi:10.1590/1089-6891v20e-34543

IMMUNOEXPRESSION OF TGF-? IN NORMAL CANINE PROSTATES AND WITH PROLIFERATIVE LESIONS

Authors

Denise Caroline Toledo Universidade Federal de Goiás (UFG), Goiânia, Goiás, Brasil https://orcid.org/0000-0001-9807-8495 (unauthenticated)
Mariana Batista Rodrigues Faleiro Universidade Federal de Goiás (UFG), Goiânia, Goiás, Brasil https://orcid.org/0000-0003-2589-1308 (unauthenticated)
Hugo Henrique Ferreira Universidade Federal de Goiás (UFG), Goiânia, Goiás, Brasil https://orcid.org/0000-0002-4431-9617 (unauthenticated)
Adriana Marques Faria Universidade Federal de Goiás (UFG), Goiânia, Goiás, Brasil https://orcid.org/0000-0002-8129-2476 (unauthenticated)
Moema Pacheco Chediak Matos Universidade Federal de Goiás (UFG), Goiânia, Goiás, Brasil https://orcid.org/0000-0002-4907-4612 (unauthenticated)
Renee Laufer Amorim Universidade Estadual Paulista (UNESP), Botucatu, São Paulo, Brasil https://orcid.org/0000-0002-8653-7938 (unauthenticated)
Veridiana Maria Brianezi Dignani de Moura Universidade Federal de Goiás (UFG), Goiânia, Goiás, Brasil https://orcid.org/0000-0001-7128-7035 (unauthenticated)

DOI:

https://doi.org/10.1590/1089-6891v20e-34543

Abstract

Abstract
The transforming growth factor-? (TGF-?), a mediator of prostatic growth induces angiogenesis and
inhibits cell proliferation. It was used in this study in order to evaluate its expression in normal
prostatic tissue and those with benign proliferative lesions, pre-malignant and malignant prostatic
diseases. A total of 54 glands with normal histomorphology, epithelial benign prostatic hyperplasia
(BPH), stromal BPH, prostatic inflammatory atrophy (PIA), prostatic intraepithelial neoplasia (PIN),
and adenocarcinoma were selected and used in the tissue microarray block (TMA). The TMA slides
were subjected to the immunohistochemistry with anti-TGF-? and its staining intensity in epithelial
and stromal cells was evaluated. There was TGF-? immunostaining by both normal tissues and those with proliferative lesions. Higher TGF-? immunostaining was observed in cells from normal
prostatic tissues and with HPB, whereas prostatic cells with PIA, PIN and carcinoma exhibited lower
immunostaining of this cytokine, suggesting the action of TGF-? in the maintenance of normal
tissue homeostasis and with benign proliferative lesion and in the progression of pre-malignant and
malignant proliferative lesions of the canine prostate.
Keywords: carcinoma, immunohistochemistry, growth factor, PIA, PIN.

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Published

2019-07-26

Issue

Vol. 20 (2019): Continuous publication

Section

VETERINARY MEDICINE

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How to Cite

TOLEDO, D. C. et al. IMMUNOEXPRESSION OF TGF-? IN NORMAL CANINE PROSTATES AND WITH PROLIFERATIVE LESIONS. Brazilian Animal Science/ Ciência Animal Brasileira, v. 20, p. 1–10, 26 Jul.2019.